attenuation of gpcr signaling
| PAG Title | attenuation of gpcr signaling |
| PAG ID | WAG000244 |
| Type | P |
| Source Link |  BioCarta |
| Publication Reference | NA |
| PAG Description | The G-protein coupled receptor (GPCR) family transduces extracellular sigls across the plasma membrane, activating cellular responses through a variety of second messenger cascades (see PKA and PKC sigling pathways). These receptors provide rapid responses to a variety of stimuli, and are often rapidly attenuated in their sigling. Failure to attenuate GPCR sigling can have dramatic consequences. One method to attenuate GPCR sigling is by removal of the stimulus from the extracellular fluid. At the sypse, removal of neurotransmitter or peptide sigling molecules is accomplished by either reuptake or degradation. Acetylcholine is removed from sypses through degradation by the enzyme acetylcholinesterase. Inhibition of acetylcholinesterase results in prolonged sigling at the neuromuscular junction, and uncontrollable spasms in humans caused by nerve gas or in insects by some insecticides. Inhibition of acetylcholinesterase is also used therapeutically to treat Alzheimer's disease, compensating for the loss of cholinergic neurons. |
| Species | Homo sapiens |
| nCoCo Score | 2,329 |
| Base PAG ID | WAG000244 |
| Human Phenotyte Annotation | |
| Curator | PAGER curation team |
| Curator Contact | PAGER-contact@googlegroups.com |
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